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This paper presents a reproduced computational model of lymphatic collecting vessels. The model was originally introduced by Bertram et al. (2011), and comprises a series of contractile segments, known as lymphangions, interconnected by secondary lymphatic valves. The model focused on elucidating the pumping behavior of contracting lymphangions and deriving pump-characteristic curves, by incorporating pressure-dependent valve resistance, passive elasticity, and active contraction terms in multiple lymphangions connected in series.
This paper presents a reproduced computational model of lymphatic collecting vessels. The model was originally introduced by Bertram et al. (2011), and comprises a series of contractile segments, known as lymphangions, interconnected by secondary lymphatic valves. The model focused on elucidating the pumping behavior of contracting lymphangions and deriving pump-characteristic curves, by incorporating pressure-dependent valve resistance, passive elasticity, and active contraction terms in multiple lymphangions connected in series.
The PBPK model of FcRn-mediated recycling of large molecules was developed and studied by deWitte et al. (2023) to characterize and predict Immunoglobulin G (IgG) disposition in plasma and tissues. This study investigated the large-molecule model in PK-Sim and its applicability to molecules with FcRn binding affinity in plasma.
The PBPK model of FcRn-mediated recycling of large molecules was developed and studied by deWitte et al. (2023) to characterize and predict Immunoglobulin G (IgG) disposition in plasma and tissues. This study investigated the large-molecule model in PK-Sim and its applicability to molecules with FcRn binding affinity in plasma.
An effort at reducing the Tong et al. (2011) model into a smaller number of equations for computational efficiency – the 'reduced' Tong model – aims at reproducing the overall behaviour without excessive detail.
An effort at reducing the Tong et al. (2011) model into a smaller number of equations for computational efficiency – the 'reduced' Tong model – aims at reproducing the overall behaviour without excessive detail.
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