The primary publication is an experimental or modelling paper describing the model, and has been accepted to a peer-reviewed journal in the field of physiological modelling. The primary publication demonstrates that the model presented in the Physiome article has been scientifically reviewed. In addition, it will typically include relevant biological background, and explain why the model was developed. Physiome articles focus on reproducibility and reuse, but do not deal with the validation nor scientific relevance of the models: these are reviewed in the Primary Paper.

A Physiome article enables you to fully describe your model implementation and its use to reproduce the findings of your primary publication. Also, any modifications made to the code since the publication of the primary publication can be finalised in order to meet reproducibility and reusability standards.

No: for original submissions, authors are encouraged to prepare their Physiome submission(s) in parallel to the primary publication. Submissions will be curated and evaluated, but not published until the primary publication is accepted and has been allocated a DOI.

At this time we require Physiome articles to be submitted in $\LaTeX$, you can use Curvenote to export to the Physiome template. We are currently exploring the use of Curvenote to directly submit articles. If this is something you are interested in, please Contact Us and let us know!

No. The Physiome article should, however, clearly describe which results from the primary publication can be reproduced by the implementation.

Code language does not have to be a standard markup language - as long as we can run it on our computers and reproduce the expected results. Provide exact instructions on how to install or access the tools required to execute the files included in your submission.

A markup languages such as CellML, SBML, and NeuroML, designed to encode a model in unambiguous form. The markup language SED-ML is designed to specify the simulation protocol for running the model with specified inputs and outputs. The use of these standard formats improves the reusability of your model implementation. See the Computational Modelling in Biology Network (COMBINE) for further information and guidance on the use of standards for modelling in biology.

The Open Modelling Exchange format, OMEX, is the technical specification defining the format of the COMBINE archive, to allow it to be used within the COMBINE network. Physiome articles include a COMBINE archive containing all files required for implementation of the model and reproduction of the simulation results presented. It can be opened by any type of ZIP reader - just rename the file extension from ".omex" to ".zip".

On the Physiome submission portal, click 'Submit revision'. There, you can replace and/or upload new files for your manuscript or supplementary material. Upon submission of the revisions, Physiome editors and curators will resume curation process by assessing the new material.

On acceptance of your submission, you will receive a link via email to view your article on the Physiome submission portal. On the portal, there is a link to the payment page for your submission, hosted by Stripe. This link can be sent to your designated third party making the payment, who will not need sign-in credentials to do so. This link does not timeout, but will be inactivated should you click 'Cancel'.

Each article has a DOI unique to it - it is not the same as the primary publication's. You will see your Physiome publication on international databases soon.

We are a new journal! We are working on appearing on various international databases.

We are an online only journal, publishing as soon as submissions are curated and accepted. Given the nature of the submissions, which are heavy on computer code, there are no physical copies of the journal.