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Original Article

Published: 2021-09-01
Last edited: 2021-09-21

Reproducibility study of the Fabbri et al. 2017 model of the human sinus node action potential

Ghotli, N. A. ORCID logo , Fabbri, A. ORCID logo , Severi, S. ORCID logo , Garny, A. ORCID logo , Nickerson, D. ORCID logo

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To cite this Physiome article, cite the whole collection at the DOI: 10.36903/physiome.16550526, and the Primary Publication at the DOI: https://doi.org/10.1113/jp273259.

All Physiome articles are published as a collection containing the manuscript as a PDF file and the model implementation as an OMEX file.

Primary Publication: Computational analysis of the human sinus node action potential: model development and effects of mutations. 2017, A. Fabbri, M. Fantini, R. Wilders, S. Severi

Abstract: The sinoatrial node (SAN) is the natural pacemaker of the mammalian heart. It has been the subject of several mathematical studies, aimed at reproducing its electrical response under normal sinus rhythms, as well as under various conditions. Such studies were traditionally done using data from rabbit SAN cells. More recently, human SAN cell data have become available, resulting in the publication of a human SAN cell model (Fabbri et al., 2017), along with its CellML version. Here, we used the CellML file provided by the model authors, together with some SED-ML files and Python scripts that we created to reproduce the main results of the aforementioned modeling study. EDITOR'S NOTE (v2): this article and its OMEX archive are republished with technical changes made to the corresponding Python scripts to remove a run-time error message displayed when executing each simulation.

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